Abstract:Diabetes is one of the most rapidly rising chronic diseases worldwide. Effective monitoring of blood glucose in diabetic patients is crucial for the treatment and the control of diabetes. As one of the many blood glucose monitoring techniques, electrochemical methods are favored for their simplicity, rapid response, and high sensitivity. Traditional precious metal materials have unique physical and chemical properties, demonstrating excellent sensing capabilities in glucose detection. However, their high cost limits their development as basic electrochemical sensing materials. Compared to others, transition metals have large reserves, stable chemical properties, and simple preparation processes in nature, making them promising in glucose sensing and becoming a mainstream research direction. Metal organic frameworks (MOFs) are porous coordination polymers composed of transition metal ions and organic ligands. Their unique structural diversity, high specific surface area, and biocompatibility make them highly promising in the field of sensors. In particular, in recent years, scientific researchers have improved the electrochemical activity of MOFs and their composite materials by regulating MOFs, such as synthesizing bimetallic MOFs and combining MOFs with conductive materials, to achieve electrocatalytic oxidation of glucose without enzyme involvement. This is particularly important in the development of enzyme free sensors. This article mainly summarizes the applications of MOFs and their composite materials in glucose enzyme free sensors in recent years, including single metal MOFs, bimetallic MOFs, MOF-metal composites, and MOF-carbon composites. It elaborates on the mechanism of detecting glucose with MOFs and their composites, and discusses the advantages and disadvantages of various MOF based glucose sensors. Finally, this article also raises the issue of MOF glucose enzyme free sensor materials and looks forward to the development of MOFs in glucose enzyme free sensors in the future.
