多孔化对钛合金羟基磷灰石涂层及生物活性的影响

Effect of Porosity on Hydroxyapatite Coating and Bioactivity of Titanium Alloys

摘要:

钛及钛合金具有良好的力学性能和生物相容性，已成为骨科和牙科修复用主要植入物材料。采用钛网扩散连接法制备医用多孔钛TA2，并在其表面沉积羟基磷灰石（HA）涂层，采用SEM和EDS法表征多孔和密实钛表面涂层的形貌和化学成分，对比成骨细胞的粘附及铺展形貌，并且进行体外细胞毒性试验。结果表明：样品经热处理，浸泡在模拟体液中14 d后可在其表面形成HA涂层，多孔钛表面细胞存活率明显高于密实钛；多孔化处理可促进培养液流动，更有利于钛表面细胞的早期粘附和增殖。

Abstract:

Due to their good mechanical properties and biocompatibility， titanium and its alloys have become the main implant materials for orthopedic and dental prosthetic applications. In this paper， medical porous titanium TA2 was prepared by diffusion bonding method of titanium mesh and hydroxyapatite （HA） coating was deposited on its surface. SEM and EDS were used to characterize the morphology and chemical composition of the porous and dense titanium surface coatings， to compare the adhesion and spreading morphology of osteoblasts， and to perform in vitro cytotoxicity tests. The results show that the HA coating can be formed on the surface of the samples even after alkali heat treatment and soaking in simulated body fluid for 14 days， and the cell viability on the porous titanium surface was significantly higher than that of dense titanium. The porosity treatment can promote the flow of culture fluid， which is more conducive to the early adhesion and proliferation of cells on the titanium surface.