氧气控制释放型生物材料研究进展

Progress of the controlled oxygen-release biomaterials

摘要:

缺氧会使得细胞死亡和组织坏死，防止细胞缺氧是影响细胞生存和工程组织植入的关键问题之一．释氧材料能为细胞和组织提供氧气支持，在组织工程和再生治疗领域显示了巨大潜力，正成为一种重要的生物材料．近年来研究者付出了诸多努力开发出高性能释氧的材料和体系，释氧材料的研究发展迅速．总结了氧气控制释放型生物材料的最新研究进展，释氧材料分为产氧材料和携氧材料两大类型，系统地总结了这两类材料在氧源化合物、载体材料和控制释氧等方面的研究进展，深入讨论了控制释氧材料的制造方法、材料传递氧气的方式和氧气控制释放性能，并讨论了释氧材料在组织工程供氧、支持缺血组织和克服肿瘤缺氧等方面的应用．释氧材料应用的关键是氧气长效控制释放，重点阐述了基于过氧化物、酶催化体系、血红蛋白类、全氟化碳和微/纳米气泡等氧源物质的可控释放体系的构建和持续释氧性能．指出了释氧材料研究存在的问题与挑战，并对今后相关研究的发展进行了展望．

Abstract:

Hypoxia will cause cell death and tissue necrosis. Preventing cell hypoxia is one of the key issues affecting cell survival and engineering tissue implantation. The oxygen-releasing materials can provide oxygen support for cells and tissues， have shown great potential in tissue engineering and regenerative therapy， and are becoming an important biomaterial. In recent years， the oxygen-releasing materials have been developed rapidly under the efforts of many researchers. We summarized the latest progress in this field in this paper. We systematically summarized the progress of two kinds of oxygen releasing materials， oxygen-generating materials and oxygen-carrying materials. We discussed the manufacturing methods of the oxygen-releasing materials， the ways of oxygen transfer and oxygen release performance， and discussed the application of oxygen releasing materials in tissue engineering application， supporting ischemic tissue and tumor hypoxia. The key to the application of oxygen-releasing materials is the long-term controlled release of oxygen. So in this paper， we focuses on the construction and continuous oxygen release performance of controlled release systems such as peroxide， enzyme catalytic system， hemoglobin， perfluorocarbon and micro/nano bubbles. The problems and challenges in the research of the oxygen-releasing materials are also pointed out， and the development of related research in the future is prospected.